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Conventional anti-folates such as aminopterin, pralatrexate, methotrexate (MTX), and pemetrexed (PMX) are the most prevalent types of DHFR inhibitors

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They are meant to help people with B12 deficiency

Rodent models have contributed significantly to our understanding of synaptic physiology, but growing evidence points to distinctive features of human neurons that are not fully captured in rodents 5 , making direct investigation in human cells essential for studying synaptic pathologies linked to cognitive decline