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(7) Sarah Wrigley, Donia Arafa, and Daniela Tropea (2017) Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging Frontiets in Cellular Neuroscience, 2017 Feb 1, Volume 11, Page 14

[PubMed: 4370423] 519

Case studies demonstrating successful resolution of reactive metabolite liabilities are abundant in the medicinal chemistry literature and often involve the following strategies: (a) removal of the functional group susceptible to bioactivation, (b) modulation of electronic character (e.g