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Skin & Tissue-Related Research Interest In tissue and skin-related research, GHK-Cu is most frequently studied for its association with collagen synthesis, extracellular matrix remodeling, and the signaling processes involved in wound-healing models

Further studies in the 2000s, (7) suggested that the GHK-Cu peptide hosts the potential to not only stimulate the collagen synthesis but also stimulate the production of tissue inhibitors, TIMP-1 and TIMP-2

However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives

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