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Importantly, RH-F/C-NPs markedly upregulated barrier-associated proteins including occludin, claudin-1, and ZO-1, underscoring their therapeutic potential for epithelial injury repair (194197)

The antiviral efficacy and drug safety was evaluated up to 192 weeks in two groups: patients continuing BSV treatment (BSV-BSV) and patients switching from TDF to BSV after 48 weeks (TDF-BSV)

Moreover, these promising preclinical findings need to be translated into clinical practice, which faces several challenges, such as determining the optimal doses to be used, enhancing the bioavailability of the molecule, ensuring that its safe to be used for the long term, and understanding the response of the molecule in different patients, which are considered critical for effective therapy design

Metabolomic results confirmed systemic glutathione depletion and mitochondrial dysfunction, as evidenced by reduced levels of S-lactoylglutathione, carnitine species, and NAD+ intermediates