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However, estrogen replacement at that time decreased the incidence of heart attack in woman to one third that of men

251 In a randomized placebo-controlled trial with 28 female participants with fibromyalgia, those who received creatine, at 5 grams four times daily for five days followed by 5 grams daily for the remainder of 16 weeks, had greater increases in muscle phosphocreatine stores and strength than those who received placebo, although no differences in fibromyalgia symptoms were detected