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Lebers hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium

The authors conclude, T3 may be considered to ameliorate some of the risk factors associated with abdominal obesity, particularly in some subgroups of obese women with a relative resistance to thyroid hormones possibly dependent on decreased peripheral deiodination of thyroxine (T4). Thus, replacement with timed-released T3 preparations to normalize the reduced intracellular T3 levels is appropriate in such patients despite so-called normal levels while, on the contrary, T4-only preparations do not address the physiologic abnormalities of such patients and should be considered inappropriate replacement for obese patients or those with insulin resistance, leptin resistance, or diabetes, as they do not address the physiologic abnormalities in this group

10.1016/j.joca.2018.08.021 87 MaT.WuJ.ChenS.BianJ.GaoG.NongL

(2020) Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment