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Dose reduction to 10 mg daily should be considered if side effects occur, with the most common reported side effects being diarrhea, nausea, headache, rash, itching, loss of hair and body weight, hypertension, chest pain, palpitation, infection, and liver failure

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Accordingly, one aspect encompassed by the present invention encompasses a diagnostic assay for determining (e.g., detecting) the presence, absence, copy number, amount and/or level of activity of a biomarker described herein (e.g., as listed in table 1 and/or table 2) in the context of a biological sample (e.g., blood, serum, cells or tissue), thereby determining whether an individual having cancer is likely to respond to a cancer therapy (e.g., at least one modulator of a biomarker listed in table 1 and/or table 2), whether in a primary cancer or a recurrent cancer