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If a therapy has good data, wed like to see it, said Makary

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There is preliminary data suggesting that methylcobalamin by itself can cause an increase in SAH, leading to incomplete reconstitution of the methionine cycle

Wang J, Cheng B, Li J, Zhang Z, Hong W, Chen X, Chen PR (2015) Chemical remodeling of cell-surface sialic acids through a palladium-triggered bioorthogonal elimination reaction