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Stage 2 has fewer levels of B12 and metabolic abnormalities, such as high homocysteine or methylmalonic acid (MMA) levels

17 Intestinal ultrasound examination was recently described as a useful modality for disease assessment and has an increasing role in tertiary IBD centres

297,298 Additionally, two other key trials of SGLT-is in people with CKD showed that canagliflozin reduced the primary composite outcome of ESRD (dialysis, transplantation, or a sustained estimated eGFR 45 ml/min/1.73m 2 and a urinary-to-creatinine ratio (uACR) 25 mg/mmol or 2045 ml/min/1.73 m 2 or established CVD are recommended for diabetic patients because of its high glucose-lowering efficacy and proven cardiorenal benefits

doi: 10.1371/journal.pone.0216711 171 PengYAoMDongBJiangYYuLChenZet al