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In AP, the pancreas releases inflammatory mediators that place mitochondria under sustained high load, leading to damage to the mitochondrial respiratory chain

Highlight: Iron Deficiency Although iron deficiency is more common in developing nations, certain populations in the US are at risk for iron deficiency: toddlers (ages 1 to 2 years) - approximately 7 percent are iron deficient adolescent and adult females (ages 12 to 49 years) - 9 to 16 percent are iron deficient pregnant females - 7 percent are iron deficient during the first trimester

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP