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While the tetrameric form of SHMT2 participate in the one-carbon unit metabolism, the dimeric form of SHMT2 has been shown to enhance the IFN- immune response [42, 43]

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doi: 10.1016/j.jhep.2021.02.027

This polymorphism is found in the heme biosynthesis pathway where it has been associated with altered toxicokinetics of lead levels and elevated blood levels of lead [100102]