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Moreover, MSU relies on ITGB1 on the surface of macrophages to activate the inflammatory signaling pathway, which suggests that targeting and inhibiting integrins on the surface of macrophages to inhibit inflammation in MSU-induced inflammatory complications is one of the research directions for precision therapy

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Enzymes that decompose ROS, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) provide the primary antioxidant defence ( Recently, a search for natural nutritional antioxidants from biological resources has gained substantial attention

HIF-1alpha inhibition improves anti-tumor immunity and promotes the efficacy of stereotactic ablative radiotherapy (SABR)