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Transferrin (TF) attaches to extracellular Fe3+ and aids in its transport into cells through transferrin receptor 1 (TfR1), where it is subsequently transformed into Fe2+ (Masaldan et al., 2018)

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Conversely, these nuclear responses feedback on mitochondrial quality control and stress tolerance, making the mitochondrianucleus axis a central component of inter-organellar communication in acinar cells