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This is rare and mechanistically distinct: Satellite cells (muscle stem cells) are activated Satellite cells divide and differentiate New muscle fibers are formed Total cell count increases Potentially breaks through genetic limitations Why IGF-1 LR3 Promotes Hyperplasia IGF-1 LR3's ability to promote hyperplasia relates to its powerful effects on satellite cells : Activates quiescent satellite cells - wakes up dormant stem cells Promotes satellite cell proliferation - increases stem cell numbers Drives differentiation - converts stem cells to mature muscle fibers Supports myoblast fusion - incorporates new cells into existing fibers Prevents satellite cell death - anti-apoptotic effects This satellite cell activation is what distinguishes IGF-1 from other growth factors and makes it unique for muscle hyperplasia research

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However, the mechanism of astrocyte-mediated neurotoxicity after stroke has also been reported recently