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Aging is often accompanied by a decline in melatonin production, which disrupts circadian rhythms and impacts sleep quality

As pleiotropic signaling molecules (Dimitrow 2009), they have been implicated in the regulation of neuronal function and thus may play a role in the pathogenesis of AD

However, large-scale randomized controlled trials in humans remain absent from Western medical literature

We evaluated the therapeutic efficacy of the natural bioactives aescin and rutin, alone and in combination with PTU, in L-thyroxineinduced hyperthyroid rats