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However, permeability increases measured in most studies are secondary to epithelial damage, which allows non-selective flux via the unrestricted pathway

Used together with atropine to treat poisoning caused by organophosphate cholinesterase inhibitors 2-PAM is not effective against the chemically different carbamate type cholinesterase inhibitors (such as neostigmine and pyridostigmine) because carbamates do not have phosphate groups and do not undergo aging

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