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4.8
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Description

Controversies exist over the TP53 mutation status dependencies of APR-246

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These studies and others like them demonstrate the thioredoxin system plays a critical role in the maintenance of the S-nitroso proteome by two distinct mechanisms: (1) reduced Trx denitrosates low-molecular weight and protein S-nitrosothiols

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This mechanism establishes a molecular basis for immune escape of tumor cells ( V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) promotes cholesterol uptake in colorectal cancer cells by facilitating endosome maturation through rabaptin-5 GDP/GTP exchange factor (RABGEF1)

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