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and 4) inhibits the pro-oxidant enzyme NADPH-oxidase that generates reactive oxygen species (ROS) (Yan et al., 2008

AOD-9604 may theoretically interact with beta-blockers by antagonising beta-3 receptor signalling, though this hasnt been clinically documented

However, more work should be performed to obtain clear information on its physiological role and therapeutic potential

Recently, this same team reported that loss of NAMPT in projection neurons cause detrimental effects on the function and structure of NJM, including impaired synaptic vesicle cycling, morphological changes to the motor endplate, alterations of skeletal muscle contractile responses, and noticeable sarcomere misalignment (Lundt et al., 2020)