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Importantly, IGF1R expression also determine RCC aggressiveness, while patients with clear-cell RCC shown kidney IGF1R expression higher than 50% have shorter survival time, a difference that becomes particularly significant after two years of follow-up.40 Moreover, after adjustment for age and stage at diagnosis, those patients with renal IGF1R expression higher than 50% had a 4.2 increased risk of death compared to those with lower renal IGF1R expression

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The growth curve results under acid stress in the present study indicated that heterologous expression of orf00404 enhanced the growth rate of the recombinant strain under acid stress conditions compared to the control strain

In esophageal cancer, the methylation process of IGFBP-L1 was associated with tumor size and TNM stage