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Therefore, a possible mechanism proposed by the authors is that the activation of the farnesoid X receptor (FXR) by exendin-4 stimulates the expression of FGF15 in the small intestine and inhibits the expression of cytochrome P450 family 7 subfamily A member 1 (Cyp7a1) in the liver through fibroblast growth factor receptor 4 (FGFR4), thereby reducing fecal bile acid excretion and liver bile acid synthesis [75]

Enhanced cartilage regeneration A 2013 study found that when white rabbits suffering from osteoarthritis (OA) were injected with Fragment 176-191 in conjunction with hydrochloric acid (HA), they experienced enhanced cartilage growth compared with those receiving HA injections alone [10]

J Nutr Sci Vitaminol 43:679684 Suganuma M, Okabe S, Oniyama M, Tada Y, Ito H, Fujiki H (1998) Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue