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This process is driven by disrupted GSH homeostasis, resulting from diminished GSH synthesis and impaired activity of two critical antioxidant systems: (1) the cystine/glutamate antiporter xCT, which imports cystine to fuel GSH production and (2) GPX4, which utilizes GSH to convert lipid peroxides into less toxic lipid alcohols (Stockwell et al., 2017

10.1016/j.freeradbiomed.2006.05.031 51 KnezW

Selain diproduksi secara alami, glutathione bisa didapatkan dalam bentuk suplemen atau dari makanan tertentu

Pure glutathione powder is a vital compound that consists of three amino acids: cysteine, glycine, and glutamate