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Safety concerns and effectiveness of long-term vitamin D and selenium use in endocrine disorders

Reported side effects are rare and typically mild temporary redness or irritation at the application site, usually resolving quickly No documented systemic toxicity in research literature at typical therapeutic doses European Medicines Agency and independent research groups rate it as well-tolerated Compatible with most standard skincare routines when used with appropriate spacing from incompatible actives Contraindications and cautions Known sensitivity or allergy to copper compounds: avoid use Active skin infections or open wounds at the injection site: delay treatment Pregnancy and breastfeeding: insufficient safety data

Therefore, athletes who plan on using a sustained-release preparation close to the in-competition period should keep all medical records in case a retroactive Therapeutic Use Exemption is required

In order to verify whether VD and thiols status are associated to the outcome of COVID-19 disease, we conducted a multicenter retrospective study among both children and adult patients with COVID-19 admitted to our Institutions during the first wave of the Italian COVID-19 outbreak