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doi: 10.1016/j.arr.2022.101735, 54

K.HuM.LuiS.HoC

Activation of GCK is thus a probable target for diabetes treatment [403]

Key findings: Improved cardiovascular function and reduced atherosclerotic markers Restored circadian rhythm and melatonin secretion in elderly subjects Improved retinal function in patients with age-related retinal degeneration Enhanced immune function and T-cell activity Extended average lifespan in a 15-year follow-up study comparing treated vs