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Moreover, in the hypothyroid animals, many of the mast cells showed partial or complete degranulation, which was in contrast to the non-activated mast cells in the animals with normal thyroid function.[ref] Other animal studies show that hypothyroidism increases mast cell infiltration into the liver and mast cell levels in the bone marrow

Other reported side effects include postural hypotension, hallucinations, and depression among over 70 patients [33]

Discussion We report 3 probands from two unrelated families with rare BBOX1 variants, L-carnitine deficiency, and elevated levels of plasma -BB, indicative of a causative effect of the BBOX1 variants affecting the final stage of the L-carnitine biosynthetic pathway

Osteoporosis has escalated into a pressing public health challenge amidst global demographic aging