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Y.ZhengR.ChenC.ChenY.LiuQ.et al (2017)

Additionally, it is subject to limited absorption by the small intestine and fast elimination by the gallbladder and its oral bioavailability is minimal

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Braz J Med Biol Res 25(2):129134 Grosso LM, Bracken MB (2005) Caffeine metabolism, genetics, and perinatal outcomes: a review of exposure assessment considerations during pregnancy