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Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knock in mouse model of Alzheimers disease

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We then expressed these proteins in HEK293T cells to determine their effect on autophagy by detecting the protein levels of SQSTM1/p62 (a substrate receptor degraded by autophagy) and LC3-II (autophagosome membrane marker protein degraded through autophagy)