glutathione cycle in mitochondria Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis Frontiers | Glutathione and mitochondria

In tumor exists a continuous two-way communication between mitochondria and the nucelus that orchestrates production of the mitochondrial encoded proteins and the nuclear-encoded mitochondria proteins to meet the cells continually changing energy and biosynthetic requirements

Because of the longer half-life time compared to the alkoxyl radical, peroxyl radical is ideal for propagation of oxidative chain reactions, while the oxidation of alkoxyl radicals produce dihydroperoxide, which is degraded to toxic aldehydes, such as 4-hydroxy-2,3-trans-nonenal, 4-hydroxy-pentanal, short chain malondialdehyde

Smith and Macfarlane62 have shown that simple phenols are major products of tyrosine metabolism by gut microflora in the distal colon

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