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Treatment with XPro1595, a selective inhibitor of solTNF that crosses the intact blood-brain barrier (BBB), in cuprizone-fed mice did not prevent toxin-induced oligodendrocyte loss and demyelination, but it permitted profound early remyelination due to improved phagocytosis of myelin debris by CNS macrophages and prevented disease-associated decline in motor performance

NF-B supports this process by upregulating immune checkpoint molecules like PD-L1 and recruiting immunosuppressive cell populations, including TAMs, MDSCs, and Tregs [81]

Combine these powerhouse ingredients by layering them, or try using a product that contains both just dont forget to do a patch test first

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