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This work was supported by: Swedish Cancer Society postdoctoral fellowship 21 0346 PT (A.M.), Royal Physiographic Society of Lund grants 2019-2023 (A.M.), Gyllenstiernska Krapperupstiftelsen grants 2021-2023 (A.M.), Gunnar Nilssons Cancer Foundation grants 2020-2023 (A.M.), Marta Winklers Foundation grant 2021-2022 (A.M.), Mary Beves Foundation grant 2021-2022 (A.M.), Maja och Halmar Leander Foundation grant 20202021 (A.M.), Swedish Childhood Cancer Foundation grant TJ2021-0068 (JTS), Swedish Childhood Cancer Foundation grant TJ2021-0137 and PR2021-0129 (O.C.B-R), KI Forskningsbidrag grant 2022-01925 (O.C.B-R), Swedish Cancer Society grant 23 2754 Pj (D.B.), Swedish Childhood Cancer Foundation grant PR2023-0006 (D.B.), Swedish Research Council grant 2021-02597 and 2023-02402 (D.B.), The Crafoord Foundation grant 20230504 (D.B.), Region Skne and Skne University Hospital Funding grant (D.B.)

It is secreted from the ciliary epithelium

Moreover, ILDR enhances the efficacy of ICI through microbiota- and BA-mediated mechanisms, including increased DC activation and CD8+ T cell recruitment, potentially driven by DCA enrichment ( Together, these findings suggest that targeting the microbiotaBA axis may improve the efficacy and tolerability of chemoradiotherapy

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