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however, to date, these effects have not been confirmed in vivo in humans [101]

This contrasts with findings from mammalian studies, in which benfotiamine supplementation increases blood and tissue thiamine level (3537), indicating potential species-specific differences in metabolic processing

Acknowledgements NST, LS, and SP are grateful to Centurion University of Technology and Management for providing research fellowship

and developing therapies that target specific CAF subpopulations or their signaling pathways to counteract the microenvironmental suppression of cell death, ultimately maximizing therapeutic efficacy on an individualized basis