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115 McCallum et al

Antioxidant interventions in autism spectrum disorders: a metaanalysis

This eventually prevents mitochondrial damage and the cytosolic release of oxidized mtDNA, a direct activator of NLRP3, limiting the processing of mature IL-1 69

A randomized, double-blind, controlled phase II trial in advanced renal cell carcinoma (RCC) demonstrated synergistic anticancer effects with the combination of the glutaminase inhibitor telaglenastat (CB-839) and the mTOR inhibitor everolimus (TelaE), which was well tolerated by patients previously treated with TKIs