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INTRODUCTION Type 1 diabetes (T1D) is a chronic autoimmune condition marked by the destruction of insulin-producing cells in the pancreas, resulting in insulin deficiency

It encourages the body to produce less of the dark Eumelanin and more of the lighter Pheomelanin

Combination therapy with metformin, pioglitazone and vitamin B12 supplementation may provide the most prominent protective effect against DNP (7,49,72,96)

80,97,98,99,100,101 A detailed history taking identifies symptoms related to sensory, motor, and autonomic dysfunction, while a physical examination focuses on sensory and motor deficits, and reflex abnormalities