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TB-500s systemic distribution means injection location barely matters for whole-body effects

The Lancet (2021) 6

Specifically, exosome vesicles secreted by tumors have been shown to home to pre-metastatic sites, where they activate pro-metastatic processes such as angiogenesis, and modify the immune contexture, so as to foster a favorable microenvironment for secondary tumor [22]

This agent has been associated with the development of syndrome of inappropriate antidiuretic hormone secretion (SIADH), leading to severe hyponatremia in patients receiving high or moderate intravenous doses of this drug[10]