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181, 11512610.1111/j.1469-8137.2008.02653.x 4 FoyerC

Mutations in the NRF2lipid peroxidationferroptosis pathway have been observed in malignancies (144)

Interestingly, the most important factors in the efficacy of a chalcone are the location of the hydroxyl groups on both aromatic rings and the number of these hydroxyls and the presence of a catechol moiety don't correlate with increasing tyrosinase inhibition potency 303