glutathione synthase drug inhibitor transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases Glutathione-Mediated Conjugation of Anticancer Drugs:

Studies that focused on the effects of administering Met and GSH alone and in combination with other compounds, other than reproduction and fertility parameters, or having rodent models without diabetes, were also excluded

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Single-strand breaks may be repaired by the oocyte after fertilization, but double-strand breaks are more difficult to repair and are often associated with severe chromosomal damage