glutathione dangereux Neuronal loss leads to neurodegeneration involving gasdermin activation Glutathione - the master antioxidant

Platinum nanoparticles act as nanozyme and catalyzed the degradation of intracellular H 2 O 2 for continuous supply of O 2 , whereas PCN-224 acts as photosensitizer and transforms the generated O 2 into singlet oxygen ( 1 O 2 ) under laser irradiation

The authors concluded that the senescent microenvironment maintained by SASP and p53-pS15 signalling promotes keloid aggressiveness and relapse, and that FOXO4-DRI targets this mechanism selectively

For all prior structures of the glutaminase isozymes, the activation loops were only visible when the enzymes were bound to allosteric inhibitors of the BPTES family of compounds

JCI Insight 5, (2)