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Oncologist 7:1419

Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia

Glossary HHCY hyperhomocysteinemia AS atherosclerosis HCY homocysteine ECs endothelial cells NO nitric oxide ROS reactive oxygen species SAM AdoMet, S-adenosylmethionine MAT methionine adenosyltransferase ATP adenosine triphosphate SAH AdoHcy, S-adenosylhomocysteine CBS cystathionine -synthase CSE cystathionine-gamma-lyase 5-methylTHF 5-methyltetrahydrofolic acid MS methionine synthase THF tetrahydrofolate BHMT betaine-homocysteine methyltransferase DHFR dihydrofolate reductase IL interleukin TNF tumor necrosis factor NF-B nuclear factor kappa-B PAI-1 plasminogen activator inhibitor-1 SASP senescence-associated secretory phenotype NOS nitric oxide synthase ADMA asymmetric dimethylarginine DDAH dimethylarginine dimethylaminohydrolase PKC protein kinase C NADPH nicotinamide adenine dinucleotide phosphate ERS endoplasmic reticulum stress ER endoplasmic reticulum Ero-1 endoplasmic reticulum oxidoreductin-1 HIF-1 hypoxia-inducible factor-1 GPX glutathione peroxidase H 2 S hydrogen sulfide ERK extracellular regulated protein kinases miR microRNA LDL low-density lipoproteins HDL high-density lipoproteins HDL-C high-density lipoprotein cholesterol ApoA1 apolipoprotein A1 TG triglyceride TC total cholesterol LDL-C low-density lipoprotein cholesterol ox-LDL oxidized low density lipoprotein VSMCs vascular smooth muscle cells ICAM-1 intercellular adhesion molecule-1 VCAM-1 vascular adhesion molecule-1 DNMT1 DNA methyltransferase 1 EPCs endothelial progenitor cells HTL homocysteine thiolactone MetRS methionyl-tRNA synthetase PQC cellular protein quality control UPR unfolded protein response UPS ubiquitin-proteasome system ACE angiotensin-converting enzyme ANG II angiotensin II LPO lipid peroxidation Cyt C cytochrome c Bax B-cell lymphoma-2 associated X protein Bcl-2 B-cell lymphoma-2 HUVECs human umbilic vein endothelial cells GLP-1 glucagon-like peptide 1 EGCG epigallocatechin gallate SIRT1 silent information regulator 1 AMPK AMP-activated protein kinase Nano-Se nanoscale selenium HCAECs human coronary artery endothelial cells DAMPs damage-associated molecular patterns PAMPs pathogen-associated molecular patterns PRRs pattern recognition receptors ASC alanine-serine-cysteine

Accelerating drug target inhibitor discovery with a deep generative foundation model