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In the presence of atropine sulfate, the benzodiazepines (diazepam, midazolam, clonazepam, loprazolam and alprazolam), mecamylamine, flunarizine, diphenylhydantoin, clonidine, CGS 19755 and Organon 6370 studied were effective

Research shows Dihexa increases dendritic spine density by 40-50% in hippocampal neurons, with these new spines demonstrating functional characteristics of mature synapses including colocalization with presynaptic markers synapsin and VGLUT1, and generation of enhanced excitatory postsynaptic currents