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doi: 10.4093/dmj.2021.0280

According to the NICE guidelines, the initial diagnostic step involves the use of IHC to identify tumors with MMR deficiency by staining for the four MMR proteinsMLH1, MSH2, MSH6, and PMS2 ( Loss of MLH1 or both MLH1 and PMS2: When this pattern is observed, MLH1 promoter hypermethylation testing of tumor DNA is recommended