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It is also noteworthy that the k cat of the two enzymes also differ by 3-fold, something that we cannot explain using static structures and may involve distinctions in active site motion, as outlined elegantly for other enzyme systems 30

While the emergence of amyloids may have begun as early as LUCA [84], the existence of a proteostasis-defending heat shock response system that arose around the same time implies that this relationship is not only evolutionarily conserved but should also be robust and effective [154]

(2018) Tesamorelin Falutz J, Allas S, Blot K, et al

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