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3234 In a meta-analysis of pharmacotherapies used for cognitive and behavioral impairment, MPH was associated with reductions in anger and aggression and enhanced psychosocial function, whereas amantadine improved aberrant behavioral symptoms

Feroz S, Muhammad N, Ratnayake J, Dias G (2020) KeratinBased materials for biomedical applications

The signaling pathway responsible for these effects appears to be cAMP/PKA/CREB, which in this study was shown to be negatively regulated by both NESF and NLP ( Figure 9 )