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RDEA3170 is currently in phase II clinical trials for the treatment of gout and asymptomatic hyperuricaemia (Yue et al., 2019)

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For example, in the study of ischemic stroke, after using rosmarinic acid (Fonteles et al., 2016), melatonin (Pei and Cheung, 2004), tropisetron (Daneshmand et al., 2011), and the traditional Chinese medicine extract Leonurus heterophyllus (Liang et al., 2011), a significant decrease in the amount and activity of MPO was observed

NREM sleep, particularly its deeper stages, is considered a hypometabolic state characterized by reduced cardiorespiratory output, reduced energic demands, and rhythmic slow oscillations