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Relative to cell growth and death and aging, ferroptosis had the highest enrichment score (Additional file 2: Figure S1)

This dual exploitation creates multiple therapeutic opportunities: disrupting cancer cell metabolism, inducing alternative cell death pathways, and modulating the immune microenvironment

483 DOX-induced cardiomyopathy results in myocardial autophagy dysfunction, accumulation of iron in both cell and mitochondria, and elevated levels of ROS, 4-HNE, and MDA