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in 2017 evaluates strategies to improve vaccine efficacy against TB by targeting innate immunity

However, the clinical application of MSCs is limited by challenges such as the difficulty in obtaining high-quality MSCs, issues with proper storage, potential tumorigenicity and the ethical complexities of the infusion process

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Similarly, biomechanical factors, such as entheseal micro-trauma, might also be involved in the pathogenesis of the articular manifestation of AS, and sentinel immune cells located in the entheses could provide links between local damage, genetic predisposition and the development of chronic inflammation