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Surprisingly, we still detected an induction effect of DMF on most of the factors studied despite NRF2 silencing (Fig

doi: 10.1016/j.phymed.2017.04.005, 63

Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178

Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice