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47 143183 10.1146/annurev.pharmtox.47.120505.105122 [DOI] [PubMed] [Google Scholar] Osenkowski P., Ye W., Wang R., Wolfe M

Indirect pharmacodynamic effects of GH-axis stimulation on coagulation factors, platelet function, and fluid balance are theoretical and have not been observed at standard ipamorelin doses (200 to 300 mcg subcutaneously)

(3) robust target deconvolution and mechanism-of-action studies across key pathways (e.g., NF-B, AMPK, PI3K/AKT/mTOR, sirtuins) to guide rational medicinal chemistry and biomarker selection