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It protects cells from oxidative stress and supports immune function by bolstering other antioxidants

Most studies using placental materials did not characterize their estrogen content

Moreover, the findings that mice with neutrophil-specific Gpx4 haploinsufficiency recapitulate key clinical features of human SLE, including autoantibodies, neutropenia, skin lesions and proteinuria, and that the treatment with a specific ferroptosis inhibitor significantly ameliorates disease severity in lupus-prone mice reveal the role of neutrophil ferroptosis in lupus pathogenesis

Anyone with underlying autoimmune or inflammatory conditions should use caution, as immune modulation may interact unpredictably