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Discussion We have created a whole body model of acetaminophen transport and metabolism that includes the details of the biochemical pathways of acetaminophen metabolism in the liver and peripheral tissues

In RLM and HepM models, PDH and 2OGDH activities were the values reported previously ( Supplementary Table S1 )

Among these derivatives, the most potent one is a hybrid of ISA/hydroxamic acid, ((3R,4R,6R,8R, 9R)-8-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl (4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl) benzoyl)- R -alaninate) (Derivative 11, Figure 2K), the IC 50 of which against the cancer cell lines were below 0.3 M (Mo et al., 2024)

IL-10 regulates inflammation by suppressing the production of cytokines such as IL-1, IL-1, IL-6, IL-8, IL-12 and TNF- in activated M and IFN- in T-cells