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The concentration of unbound IGF-I in the circulation is likely to be proportional to unbound IGF-I concentrations in the tissues, but they are not equal and may have different relationship in different target tissues with differentially-expressed IGFBPs

However, persistent twitching in the stomach area especially twitching of the abdomens left side or twitching under the right rib cage warrants evaluation to rule out gastrointestinal causes, hiatal hernia, or referred nerve irritation