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Statistically significant improvements in metabolic status were many including: total sulfate (+17%, p = 0.001), S-adenosylmethionine (SAM

Each component is associated in published literature with a distinct mechanistic pathway: copper-dependent ECM-related signaling (GHK-Cu), inflammatory pathway modulation (KPV), angiogenesis pathway markers (BPC-157), and actin-driven cell-migration assays (TB-500)

Another study [19] reported increased serum levels of IL-1R antibody in FM patients and hypothesized the role of IL-6 toward the hypersensitivity to pain, fatigue, and depression